We “BREW” success
- Food Technology – Fish-Free Seafood
- Used the BREW Method™ to re-align R&D with business goals:
- Discontinued 3 Lines of Effort (LOEs) that were not aligned.
- Pivoted 2 LOEs to align better with product requirements.
- Filled Resource gaps with external partners (CROs).
- Delivered critical technical unlocks for manufacturing.
- Achieved self-GRAS declaration in 3 months.
- Successful product launch in Chicago Michelin Star Restaurant in 10 months!
- Used the BREW Method™ to re-align R&D with business goals:
- Medical Device (IVD) Development
- Led the development of a rapid (<10 minute) multi-plex real-time PCR diagnostic device, instrument and assay, from concept to 510k readiness including all DHF documentations (FMEAs, PRA, URRA, PRD, MRD, etc.)
- Led Verification and Flex testing for assay, and consumable device.
- Delivered novel DNA/RNA collection, extraction and preservation techniques.
- Authored a patent on a novel cell-lysis product for gram+ and fungal pathogens.
- Food Technology/Precision Fermentation
- Delivered engineered strains and bioprocesses for production of human breast milk glycoproteins.
- Fundraising: secured $4MM in an oversubscribed seed round and $20MM in Series A financing.
- Established a platform to produce palm oil in oleaginous yeast.
- Microbiome Therapeutics
- Designed a cGMP-compliant cleanroom facility for manufacture of skin probiotics.
- Scaled fermentation from bench to 5L and 50L leading to successful market testing and eventual acquisition by Crown Laboratories.
- Currently working on projects developing probiotic solutions for collagen elasticity and hidradenitis suppurativa.
Biofuels/Industrial Microbiology – BREW™ Success
- Balancing:
- Established Line of Effort (LOE) to validate new unit ops for commercial plant at bench scale.
- Pivoted strain engineering LOEs to align with commercial goals (productivity metrics).
- Discontinued a process engineering LOE that was not aligned and a deep cost.
- Resourcing:
- Raised new funding.
- Hired new personnel to fill gaps.
- Built an internal Multi-omics platform to reduce long turn around times with CROs.
- Execution:
- Created timelines with clearly defined milestones (KPIs) and deliverables.
- Established regular operational reviews to ensure projects were on-track.
- Wins!
- Celebrated hitting critical titer and productivity KPIs.
- Achieved GRAS certification for single-cell protein.
- Signed a $20MM joint development agreement with a South Korean Company.
- AgTech/Crop Protection
- Delivered 10% improved strain/process for Spinosad using an improved high throughput screening platform.
- Delivered 20% improved strain for Spinetoram using a novel genetic engineering approach.
- Achieved approval for Inatreq® precursor (UK-2A). Performed risk reviews, improved strains and processes.
- Commissioned and Qualified two ISO-6/7 cleanrooms.
- Received approval for development of a novel “green” biosurfactant (soap).
