Selection, Screens, and Hidden Assumptions
How the questions we ask determine the answers we find.
Many scientific tools are designed to reveal truth. But every screen, assay, and selection process carries assumptions about what matters and what success looks like.
This series explores how experimental design shapes discovery – and why the biology we uncover is often a reflection of the questions we choose to ask.
You High Throughput Screen Isn’t Broken
January 9, 2026
After 20+ years building and fixing high-throughput screens, I’ve learned one rule that never fails: “You always get what you screen for.”
Assay conditions shape the biology that emerges from a screen so when hits look great in HTS but fall apart later, the screen usually isn’t broken – the assumptions are.
What if your best hit already slipped through your screen?
March 26, 2026
High Throughput gives you more shots on goal. But that doesn’t mean they are quality shots.
You Always Get What You Screen For
June 4, 2026
Assay conditions are not neutral. They determine what biology you’re able to see.